Han Q D
Institute of Vascular Medicine, Third Hospital, Beijing Medical University.
Sheng Li Ke Xue Jin Zhan. 1995 Apr;26(2):103-9.
According to pharmacological characteristics and molecular cloning, adrenoceptor is divided into 3 types, and each type contains at least 3 subtypes. The molecular structure of adrenoceptor fits common model of G protein coupled receptors on membrane surface. The structure-function relationship has been basically elucidated by mutation techniques. The ligand binding characteristics are decided by the structures in transmembrane domains, while the G protein coupling sites are in the third intracellular loop. There are extensive crosstalks among the subtypes of adrenoceptor. According to the mechanisms, the crosstalks can be divided into 4 types.
根据药理学特性和分子克隆，肾上腺素能受体分为3种类型，每种类型至少包含3个亚型。肾上腺素能受体的分子结构符合膜表面G蛋白偶联受体的通用模型。结构-功能关系已通过突变技术基本阐明。配体结合特性由跨膜结构域中的结构决定，而G蛋白偶联位点位于第三个细胞内环中。肾上腺素能受体亚型之间存在广泛的相互作用。根据作用机制，这些相互作用可分为4种类型。
