Roodt L, Rees D
Department of National Health and Population Development, University of the Witwatersrand, Johannesburg.
S Afr Med J. 1995 Jun;85(6):522-5.
To determine the prevalence of sensitisation to soy bean measured by specific IgE and skin prick tests (SPTs) and to examine the association between evidence of sensitisation to soy bean allergens and symptoms of allergic disease.
Cross-sectional study. Questionnaire survey. A venous blood sample was taken for specific IgE testing, and SPTs for common allergens and soy bean dust were performed.
Soy bean mill.
A volunteer sample of 22 workers exposed to soy bean dust; the first 20 non-exposed workers presenting to the National Centre for Occupational Health clinic formed the control group.
Immunological tests for sensitisation and symptoms of respiratory and allergic disease.
Eight of the exposed workers had positive skin reactions to either full-fat or defatted soy bean. None of the controls was SPT-positive. Eight of the exposed workers had increased levels of soy-specific IgE of whom only 4 were SPT-positive and had an increased level of soy-specific IgE. One of the control workers had an increased level of soy-specific IgE. Workers with an increased specific IgE or SPT positive to soy bean did not have more symptoms than workers with negative tests. However, work-related breathlessness was significantly higher in the exposed group (P < 0.05).
The data suggest that the immunological tests for sensitisation were not useful in identifying workers with soy bean-related disease but that tests for sensitisation were linked to exposure.
通过特异性IgE和皮肤点刺试验（SPT）测定大豆致敏的患病率，并研究大豆过敏原致敏证据与过敏性疾病症状之间的关联。
横断面研究。问卷调查。采集静脉血样本进行特异性IgE检测，并对常见过敏原和大豆粉尘进行SPT。
大豆加工厂。
22名接触大豆粉尘的工人志愿者样本；前20名到国家职业健康诊所就诊的未接触工人组成对照组。
致敏的免疫学检测以及呼吸道和过敏性疾病的症状。
8名接触大豆的工人对全脂或脱脂大豆有阳性皮肤反应。对照组中无人SPT呈阳性。8名接触大豆的工人大豆特异性IgE水平升高，其中只有4人SPT呈阳性且大豆特异性IgE水平升高。1名对照工人大豆特异性IgE水平升高。大豆特异性IgE升高或对大豆SPT呈阳性的工人与检测呈阴性的工人相比，症状并未更多。然而，接触组中与工作相关的呼吸急促明显更高（P<0.05）。
数据表明，致敏的免疫学检测对识别患有大豆相关疾病的工人并无用处，但致敏检测与接触有关。
