Vejtorp M, Petersen K, Andersen A N, Yue B Z, Meng B F
gynaekologisk-obstetrisk afdeling, Amtssygehuset i Herlev.
Ugeskr Laeger. 1995 Jul 17;157(29):4131-4.
The purpose of the study was to determine the effect of the presence of a hydrosalpinx and of increasing age on the pregnancy rate after in vitro fertilization (IVF). The presence or absence of a hydrosalpinx was determined by transvaginal ultrasonography before hormonal stimulation of the follicles. The study included 741 women treated in 1090 consecutive cycles in which at least one oocyte was aspirated. The pregnancy rate in 104 cycles in women who had a hydrosalpinx was 6%. In 813 cycles in women with tubal infertility, but without a hydrosalpinx, the rate was 21% (p < 0.0005). A similar pregnancy rate was found in women with unexplained infertility after treatment in 257 cycles. The pregnancy rate in women without a hydrosalpinx decreased from 25% among the women who were 22-29 years old to 11% in the women who were 40-44 years old. In conclusion, the presence of a hydrosalpinx decreases the pregnancy rate after IVF. As tubostomy to improve fertility generally carries a poor prognosis, a salpingectomy prior to IVF may be preferable. Owing to the age-related reduction of the pregnancy rate, IVF should not be put off when indicated for treatment of infertility.
本研究的目的是确定输卵管积水的存在以及年龄增长对体外受精（IVF）后妊娠率的影响。在对卵泡进行激素刺激之前，通过经阴道超声检查确定是否存在输卵管积水。该研究纳入了741名女性，她们接受了1090个连续周期的治疗，每个周期至少抽吸一个卵母细胞。有输卵管积水的女性在104个周期中的妊娠率为6%。在813个患有输卵管性不孕但无输卵管积水的女性周期中，妊娠率为21%（p<0.0005）。在257个周期的治疗后，不明原因不孕的女性也有类似的妊娠率。无输卵管积水的女性妊娠率从22 - 29岁女性中的25%降至40 - 44岁女性中的11%。总之，输卵管积水的存在会降低IVF后的妊娠率。由于输卵管造口术改善生育能力的预后通常较差，IVF前进行输卵管切除术可能更可取。由于妊娠率与年龄相关而降低，在有指征治疗不孕时，不应推迟IVF。
