Ratajczak J, Halasa M, Ratajczak M Z
Zakładu Patologii Komórki Pomorskiej Akademii Medycznej w Szczecinie.
Acta Haematol Pol. 1995;26(2):171-7.
The influence of macrophage inflammatory protein-1 alpha (MIP-1 alpha) on cloning efficiency of human erythroid progenitors was evaluated. In our hands, in performed experiments in serum supplemented as in serum free cloning culture systems we did not observe any effect of MIP-1 alpha on erythroid colony formation by human CD34+ bone marrow cells. Therefore, our data did not confirm the possibility of the direct role of MIP-1 alpha in the pathogenesis of the anaemia of chronic disease.
评估了巨噬细胞炎性蛋白-1α（MIP-1α）对人红系祖细胞克隆效率的影响。在我们的实验中，无论是在补充血清的还是无血清的克隆培养系统中进行实验，均未观察到MIP-1α对人CD34+骨髓细胞形成红系集落有任何影响。因此，我们的数据并未证实MIP-1α在慢性病贫血发病机制中直接起作用的可能性。
