Takeda T, Takeuchi S, Kimura T, Saito H
Department of Otolaryngology, Kochi Medical School, Japan.
Acta Otolaryngol. 1995 May;115(3):382-5. doi: 10.3109/00016489509139333.
Changes in cochlear blood circulation (CoBC) and perilymphatic pressure (Pp) after administration of physiological saline and 50% glycerol (12 ml/kg) were measured simultaneously in guinea pigs to examine the influence of glycerol on CoBC and Pp. The CoBC was measured by the laser-Doppler method. Although neither CoBC nor Pp changed after administration of physiological saline, glycerol produced a marked increase in CoBC and a slight decrease in Pp in 11 of 15 animals. However, the increase in CoBC was transient; CoBC reached a peak as soon as 30 min after glycerol administration and then returned rapidly to its initial value within 1 h after administration, although the Pp was still decreasing. Therefore, the response of CoBC to glycerol does not seem to be directly related to hyperosmolarity due to glycerol administration.
在豚鼠中同时测量了给予生理盐水和50%甘油（12毫升/千克）后耳蜗血液循环（CoBC）和外淋巴压力（Pp）的变化，以研究甘油对CoBC和Pp的影响。CoBC通过激光多普勒法测量。给予生理盐水后，CoBC和Pp均未发生变化，但在15只动物中的11只中，甘油使CoBC显著增加，Pp略有下降。然而，CoBC的增加是短暂的；甘油给药后30分钟CoBC即达到峰值，给药后1小时内迅速恢复到初始值，尽管Pp仍在下降。因此，CoBC对甘油的反应似乎与甘油给药引起的高渗性没有直接关系。
