Yamashita H, Tahara T, Shimogori H, Takahashi M
Department of Otolarygology, Yamagichi University School of Medicine, Japan.
Acta Otolaryngol. 1995 May;115(3):462-4. doi: 10.3109/00016489509139349.
The expression of laminin in the vestibular ganglia and nerves in herpes simplex virus I (HSV-I) infectious chick embryos was examined by immuno-histochemistry. In 9-day-old normal chick embryos, the surface of the vestibular ganglion cells and the vestibular nerves were labelled with laminin, while, in HSV-I infectious chick embryos, the staining of laminin in the vestibular ganglia and nerves was very weak. These results suggest that HSV-I injures vestibular ganglia and nerves, and that laminin is a good marker of the degeneration and innervation of developing vestibular nerves.
采用免疫组织化学方法检测单纯疱疹病毒I型（HSV-I）感染鸡胚中纤连蛋白在前庭神经节和神经中的表达。在9日龄正常鸡胚中，前庭神经节细胞表面和前庭神经均有纤连蛋白标记，而在HSV-I感染的鸡胚中，前庭神经节和神经中纤连蛋白的染色非常弱。这些结果表明，HSV-I损伤前庭神经节和神经，且纤连蛋白是发育中前庭神经退变和神经支配的良好标志物。
