Yamashita H, Bagger-Sjöbäck D, Sekitani T
Department of Otolaryngology, Yamaguchi University School of Medicine, Japan.
Acta Otolaryngol Suppl. 1993;503:166-9. doi: 10.3109/00016489309128101.
The expression of laminin, Na+, K(+)-ATPase, carbonic anhydrase (CA) isoenzymes and calcitonin gene-related peptide (CGRP) in the human fetal vestibular ganglia was studied by immuno-histochemistry. In the 12-week-old fetus, the cell surface of the vestibular ganglion cells was positive for laminin. In the 14-week-old fetus, a few vestibular ganglion cells were positive for CA II. In the 15-week-old fetus, the cell surface of the vestibular ganglion cells and the nerve fibers were strongly labelled with laminin. CGRP positive nerve fibers were found in the ganglia. In the 16-week-old fetus, some ganglion cells were labelled with Na+, K(+)-ATPase. CA II stained the vestibular nerve fibers as well as the vestibular ganglion cells. The results suggest that these substances may be used as histological markers of maturation and innervation of the human vestibular ganglion cells.
采用免疫组织化学方法研究了人胎儿前庭神经节中层粘连蛋白、钠钾-ATP酶、碳酸酐酶（CA）同工酶及降钙素基因相关肽（CGRP）的表达。在12周龄胎儿中，前庭神经节细胞的细胞表面层粘连蛋白呈阳性。在14周龄胎儿中，少数前庭神经节细胞CA II呈阳性。在15周龄胎儿中，前庭神经节细胞的细胞表面和神经纤维被层粘连蛋白强烈标记。在神经节中发现了CGRP阳性神经纤维。在16周龄胎儿中，一些神经节细胞被钠钾-ATP酶标记。CA II使前庭神经纤维和前庭神经节细胞均被染色。结果表明，这些物质可用作人前庭神经节细胞成熟和神经支配的组织学标志物。
