Uko G P, Griffiths M, Dawkins R L, Cobain T, Mohammed I, Hedo C, Okafor G, Umotong A B
National Institute for Medical Research, Lagos, Nigeria.
Afr J Med Med Sci. 1994 Dec;23(4):385-9.
Concentrations of immunoglobulins (IgA, IgG and IgM) were measured in Nigerians with (HIV) infection. Considerable elevations up to two-fold the reference values were observed for IgG and IgM in the patient group as a whole but elevations in IgA concentration were least marked albeit significantly different from the healthy subjects. Elevation of a particular isotype was not always concomitant with elevation of the other major classes in the same patient. Overall, these elevations were observed in both symptomatic and asymptomatic infected subjects. Further analysis of IgG hyperglobulinemia showed that increases in this major class may be due to increased IgG2 subclass concentrations. It is suggested that elevation of IgG2 subclass in Nigerians with HIV infection and not IgG1 or IgG3 may be due to genetic and environmental factors rather than variation in the strain of the virus.
对感染艾滋病毒（HIV）的尼日利亚人进行了免疫球蛋白（IgA、IgG和IgM）浓度的检测。在整个患者组中，观察到IgG和IgM浓度显著升高，高达参考值的两倍，但IgA浓度的升高最不明显，尽管与健康受试者有显著差异。在同一患者中，特定同种型的升高并不总是与其他主要类别同时升高。总体而言，在有症状和无症状感染的受试者中均观察到了这些升高。对IgG高球蛋白血症的进一步分析表明，这一主要类别浓度的增加可能是由于IgG2亚类浓度的增加。有人提出，感染HIV的尼日利亚人IgG2亚类升高而非IgG1或IgG3升高，可能是由于遗传和环境因素，而非病毒株的变异。
