Kaeser P, Revelly M L, Frei P C
Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Allergy. 1994 Sep;49(8):626-9. doi: 10.1111/j.1398-9995.1994.tb00130.x.
We investigated whether some cases of chronic urticaria of unexplained cause might be related to food allergy which had remained undetected during routine examination. This investigation was undertaken as the consequence of the availability of a new in vitro assay for specific IgE with increased sensitivity. The following three groups of subjects were studied: 1) a control group of 60 nonatopic subjects, 2) 60 patients with allergy to perennial aeroallergens without skin involvement, and 3) 60 patients suffering from chronic urticaria with no evidence of any triggering factor despite careful clinical investigation. Specific IgE against 19 food allergens frequently involved in urticaria were investigated in all subjects with the new CAP System (Pharmacia). Positive results (CAP > 0.70 kU/l) for one or more food allergens were found in none of the nonatopic controls, in six of the subjects with respiratory allergy, and in 16 of the urticaria patients. The use of an in vitro test with an increased sensitivity allowed us to detect a significant prevalence of IgE specific for food allergens in patients with chronic urticaria of unknown origin. This suggests that, in several of those patients, chronic urticaria might be triggered by a food allergy undetected by the usual methods.
我们调查了某些病因不明的慢性荨麻疹病例是否可能与食物过敏有关，而这些食物过敏在常规检查中未被发现。这项调查是由于一种新的体外特异性IgE检测方法灵敏度提高而得以进行的。我们研究了以下三组对象：1）60名非特应性对照对象；2）60名对常年性气传变应原过敏但无皮肤受累的患者；3）60名患有慢性荨麻疹的患者，尽管经过仔细的临床检查，仍未发现任何触发因素。使用新的CAP系统（Pharmacia）对所有对象检测了针对19种常见于荨麻疹的食物变应原的特异性IgE。在非特应性对照对象中，未发现任何一种食物变应原呈阳性结果（CAP > 0.70 kU/l）；在呼吸道过敏患者中，有6例呈阳性；在荨麻疹患者中，有16例呈阳性。使用灵敏度更高的体外检测方法使我们能够发现，在病因不明的慢性荨麻疹患者中，食物变应原特异性IgE的患病率显著升高。这表明，在其中一些患者中，慢性荨麻疹可能由常规方法未检测到的食物过敏引发。
