Montan P, Zetterström O, Eliasson E, Strömquist L H
St Eriks Eye Hospital, Stockholm, Sweden.
Allergy. 1994 Sep;49(8):637-40. doi: 10.1111/j.1398-9995.1994.tb00132.x.
Twelve patients with seasonal allergic conjunctivitis caused by either birch or timothy grass pollen were challenged out of season in both eyes, with the relevant allergen. Itching, redness, swelling, and tearing were assessed on a 0-3 scale. When a positive reaction, i.e., at least 4 points, had occurred in both eyes, one drop of 2% sodium cromoglycate was administered to one eye and one drop of placebo to the other eye in each patient, in a double-blind, randomized fashion. Symptoms were then assessed after 2, 10, 30, and 60 min. Sodium cromoglycate was statistically better than placebo in reducing the symptoms at 2, 10, and 30 min after the treatment had been administered, showing that topical application of 2% sodium cromoglycate can quickly relieve ongoing symptoms of allergic inflammation in the eye.
12名由桦树或梯牧草花粉引起季节性过敏性结膜炎的患者在非花粉季节接受了双眼相关过敏原激发试验。对瘙痒、眼红、肿胀和流泪情况按0至3级进行评估。当双眼均出现阳性反应（即至少4分）时，以双盲、随机的方式为每位患者的一只眼滴入一滴2%色甘酸钠，另一只眼滴入一滴安慰剂。然后在2分钟、10分钟、30分钟和60分钟后评估症状。在给药后2分钟、10分钟和30分钟时，色甘酸钠在减轻症状方面在统计学上显著优于安慰剂，表明局部应用2%色甘酸钠可迅速缓解眼部过敏性炎症的现有症状。
