Pignataro L D, Broich G, Lavezzi A M, Biondo B, Ottaviani F
1st Department of Otorhinolaryngology, University of Milan, IRCCS Ospedale Maggiore, Policlinico, Italy.
Anticancer Res. 1995 Jul-Aug;15(4):1517-20.
Laryngeal hyperkeratotic lesions can progress to fully developed malignant carcinoma in some cases. These premalignant lesions are proliferative disorders whose potential for further tumour progression is perhaps difficult to assess by mere histology. Immunostaining with PCNA, a protein correlated with cell proliferation, has been used to study tissue behavior in 30 cases of premalignant laryngeal vocal chord lesions treated by epithelial stripping in microlaryngoscopy, 15 of whom had no progression and 15 had recurrence and final development of full malignancy. The results showed a statistically significantly higher PCNA-index in the cases which underwent further tumour progression towards malignancy. PCNA testing may thus be suggested as a marker for tumour progression potential and help in determining clinical treatment choices.
在某些情况下，喉角化病变可发展为完全成熟的恶性癌。这些癌前病变是增殖性疾病，仅通过组织学可能难以评估其进一步肿瘤进展的潜力。增殖细胞核抗原（PCNA）是一种与细胞增殖相关的蛋白质，已用于研究30例经显微喉镜上皮剥脱术治疗的喉声带癌前病变的组织行为，其中15例无进展，15例复发并最终发展为完全恶性。结果显示，在进一步向恶性肿瘤进展的病例中，PCNA指数在统计学上显著更高。因此，PCNA检测可作为肿瘤进展潜力的标志物，并有助于确定临床治疗选择。
