Ivanova I V, Khristova K R, Moncheva P A, Miteva V I
Antibiot Khimioter. 1995 Apr;40(4):12-6.
The influence of nigericin (nandavir) on the organism producing it (Streptomyces hygroscopicus 155) was studied with respect to the synthesis of protein, RNA and DNA. The resistance of the mycelium of different ages to the exogenic antibiotic was investigated. Exogenic nigericin had a more marked inhibitory effect on the macromolecular synthesis in a nonproductive variant of the strain. The antibiotic sensitivity of the mycelium in both the variants (productive and nonproductive) depended on the culture age. It was suggested that there were not less than two mechanisms of the protection from the own antibiotic in the organism.
就蛋白质、RNA和DNA的合成而言，研究了尼日利亚菌素（南达霉素）对产生它的生物体（吸水链霉菌155）的影响。研究了不同年龄菌丝体对外源抗生素的抗性。外源尼日利亚菌素对该菌株的非生产变体中的大分子合成具有更显著的抑制作用。两种变体（生产性和非生产性）中菌丝体的抗生素敏感性均取决于培养年龄。有人提出，生物体中存在不少于两种免受自身抗生素影响的保护机制。
