Danova S T, Moncheva P A, Antonova S K, Ivanova I V
Antibiot Khimioter. 1997;42(4):12-5.
The influence of Ca2+ on the growth, antibiotic production and differentiation of Streptomyces albogriseolus 444 was studied. Consumption of the calcium ions by the strain was followed up. It was shown that Ca2+ changed the dynamics of the biomass accumulation and had no significant effect on the antibiotic production. Calcium present in the medium was assimilated more intensively during the first 24 hours of the strain growth. The own antibiotic nigericin exogenously added to the medium increased the calcium assimilation. In the presence of Ca2+ the nigericin stimulation of the strain differentiation was higher.
研究了Ca2+对浅灰链霉菌444生长、抗生素产生及分化的影响。跟踪了该菌株对钙离子的消耗情况。结果表明，Ca2+改变了生物量积累的动态，而对抗生素产生无显著影响。在菌株生长的最初24小时内，培养基中存在的钙被更强烈地同化。外源添加到培养基中的自身抗生素尼日利亚菌素增加了钙的同化。在Ca2+存在的情况下，尼日利亚菌素对菌株分化的刺激作用更强。
