Sverdlova A N, Solov'eva I V, Nefelova M V
Antibiot Khimioter. 1995 Apr;40(4):17-24.
A macrotetrolide preparation including nonactin (about 75 per cent), monactin (about 23 pr cent) and traces of dinactin and trinactin was analyzed with the method of UV spectroscopy. It was shown to form hydrophobic complexes in organic solvents with picrates of univalent cations of ammonium, potassium and sodium. The complex strength depended not only on the cation nature, but also on the solvent and pH of the picrate aqueous solutions. The comparison of methylene chloride used for tetrananactin with chloroform demonstrated that nonactin formed stable complexes in chloroform at neutral pH of the aqueous phase, a solution of picric acid and ammonium chloride.
用紫外光谱法分析了一种包含约75%的缬氨霉素、约23%的单活菌素以及痕量双活菌素和三活菌素的大环四醇酯制剂。结果表明，它在有机溶剂中能与铵、钾和钠等一价阳离子的苦味酸盐形成疏水络合物。络合物的强度不仅取决于阳离子的性质，还取决于苦味酸盐水溶液的溶剂和pH值。将用于分析四活菌素的二氯甲烷与氯仿进行比较，结果表明，在水相、苦味酸溶液和氯化铵的中性pH条件下，缬氨霉素在氯仿中能形成稳定的络合物。
