Nefelova M V, Sverdlova A N, Egorov N S
Antibiot Med Biotekhnol. 1985 Mar;30(3):163-6.
White crystalline antibiotically active substances identified as macrotetrolides were isolated from the mycelium of four actinomycetous strains, i.e. S. chrysomallus var. I, S. chrysomallus var. III, S. chrysomallus var. carotenoides and S. chrysomallus var. macrotetrolidi. The component composition of the macrotetrolide antibiotics of all four strains was identical. It was characterized by predominance of nonactin, a lower homologue. The composition ratio was the following: 69-79 per cent of nonactin, 19-29 per cent of monactin, 1-3 per cent of dinactin and the traces of trinactin and tetranactin. The strains differed in the intensity of production of the macrotetrolides and the ability to synthesize other biologically active substances.
从四种放线菌菌株，即金色链霉菌变种I、金色链霉菌变种III、金色链霉菌类胡萝卜素变种和金色链霉菌大内酯变种的菌丝体中分离出被鉴定为大内酯类的白色结晶抗生素活性物质。所有四种菌株的大内酯类抗生素的成分组成相同。其特征是以低级同系物诺卡菌素占主导。组成比例如下：诺卡菌素占69 - 79%，单诺卡菌素占19 - 29%，双诺卡菌素占1 - 3%，还有痕量的三诺卡菌素和四诺卡菌素。这些菌株在大内酯类的产生强度和合成其他生物活性物质的能力方面存在差异。
