Landis W J
Department of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA.
Bone. 1995 May;16(5):533-44. doi: 10.1016/8756-3282(95)00076-p.
High-voltage electron-microscopic tomographic (3D) studies of the ultrastructural interaction between mineral and organic matrix in a variety of calcified tissues reveal different crystal structural and organizational features in association with their respective organic matrices. In brittle or weak pathologic or ectopic calcifications, including examples of osteogenesis imperfecta, calciphylaxis, calcergy, and dermatomyositis, hydroxyapatite crystals occur in various sizes and shapes and are oriented and aligned with respect to collagen in a manner which is distinct from that found in normal calcified tissues. A model of collagen-mineral interaction is proposed which may account for the observed crystal structures and organization. The results indicate that the ultimate strength, support, and other mechanical properties provided by a calcified tissue are dependent in part upon the molecular structure and arrangement of its constituent mineral crystals within their organic matrix.
对多种钙化组织中矿物质与有机基质超微结构相互作用的高压电子显微镜断层扫描（3D）研究揭示，与其各自的有机基质相关联，存在不同的晶体结构和组织特征。在脆性或脆弱的病理性或异位钙化中，包括成骨不全、钙过敏、钙能反应和皮肌炎的例子，羟基磷灰石晶体呈现出各种大小和形状，并且相对于胶原蛋白的取向和排列方式与正常钙化组织中发现的不同。提出了一种胶原蛋白 - 矿物质相互作用模型，该模型可能解释所观察到的晶体结构和组织。结果表明，钙化组织提供的极限强度、支撑力和其他力学性能部分取决于其组成矿物晶体在有机基质中的分子结构和排列。
