在使用尼古丁贴片治疗期间，体育锻炼会增加血浆中尼古丁的浓度。
Physical exercise increases plasma concentrations of nicotine during treatment with a nicotine patch.
作者信息
Klemsdal T O, Gjesdal K, Zahlsen K
机构信息
Oslo University Hospital Ullevål, Department of Cardiology, Norway.
出版信息
Br J Clin Pharmacol. 1995 Jun;39(6):677-9. doi: 10.1111/j.1365-2125.1995.tb05728.x.
Abstract
The effect of physical exercise on plasma nicotine concentrations was studied in eight healthy subjects treated with a nicotine patch releasing 14 mg 24 h-1. After 11 h of patch application, plasma nicotine concentrations were measured before and after 20 min of moderate bicycle exercise, or 20 min of rest. Mean plasma nicotine concentration increased from 9.8 to 11.0 ng ml-1 (P = 0.015) during physical exercise, and fell non-significantly from 10.5 to 10.2 ng ml-1 during rest. The increase in plasma nicotine concentration during exercise is similar to that observed for transdermal nitroglycerin, and may be related to an exercise-induced increase in blood flow in the patch area.
摘要
在8名使用24小时释放14毫克尼古丁贴片的健康受试者中，研究了体育锻炼对血浆尼古丁浓度的影响。在贴片使用11小时后，在进行20分钟适度自行车运动或20分钟休息前后测量血浆尼古丁浓度。体育锻炼期间，平均血浆尼古丁浓度从9.8纳克/毫升增加到11.0纳克/毫升（P = 0.015），休息期间从10.5纳克/毫升降至10.2纳克/毫升，下降不显著。运动期间血浆尼古丁浓度的增加与经皮硝酸甘油观察到的情况相似，可能与运动引起的贴片区域血流增加有关。
相似文献
1
Physical exercise increases plasma concentrations of nicotine during treatment with a nicotine patch.在使用尼古丁贴片治疗期间，体育锻炼会增加血浆中尼古丁的浓度。
Br J Clin Pharmacol. 1995 Jun;39(6):677-9. doi: 10.1111/j.1365-2125.1995.tb05728.x.
2
Plasma levels of nicotine and safety of smokers wearing transdermal delivery systems during multiple simultaneous intake of nicotine and during exercise.在同时多次摄入尼古丁及运动期间，吸烟者佩戴经皮给药系统时的血浆尼古丁水平及安全性。
J Clin Pharmacol. 1997 Aug;37(8):728-36. doi: 10.1002/j.1552-4604.1997.tb04360.x.
3
Effect of exercise on transdermal nicotine release in healthy habitual smokers.运动对健康习惯性吸烟者经皮尼古丁释放的影响。
Int J Clin Pharmacol Ther. 2005 May;43(5):239-43. doi: 10.5414/cpp43239.
4
Effects of transdermal nicotine or smoking on nicotine concentrations and maternal-fetal hemodynamics.经皮尼古丁或吸烟对尼古丁浓度及母婴血流动力学的影响。
Obstet Gynecol. 1997 Oct;90(4 Pt 1):569-74. doi: 10.1016/s0029-7844(97)00309-8.
5
Pharmacokinetic comparison of two nicotine transdermal systems, a 21-mg/24-hour patch and a 25-mg/16-hour patch: a randomized, open-label, single-dose, two-way crossover study in adult smokers.两种尼古丁透皮系统（21 毫克/24 小时贴片和 25 毫克/16 小时贴片）的药代动力学比较：一项在成年吸烟者中进行的随机、开放标签、单剂量、两周期交叉研究。
Clin Ther. 2010 Jun;32(6):1140-8. doi: 10.1016/j.clinthera.2010.06.008.
6
Comparison of plasma nicotine concentrations after application of nicoderm (nicotine transdermal system) to different skin sites.
J Clin Pharmacol. 1992 Jun;32(6):576-81. doi: 10.1177/009127009203200615.
7
Influence of exercise on nitroglycerin plasma concentrations after transdermal application.运动对经皮应用硝酸甘油后血浆浓度的影响。
Br J Clin Pharmacol. 1990 Aug;30(2):292-6. doi: 10.1111/j.1365-2125.1990.tb03778.x.
8
Exposure to high ambient temperature increases absorption and plasma concentrations of transdermal nicotine.暴露于高环境温度会增加经皮尼古丁的吸收和血浆浓度。
Clin Pharmacol Ther. 1996 Sep;60(3):308-15. doi: 10.1016/S0009-9236(96)90057-0.
9
Bioavailability and absorption kinetics of nicotine following application of a transdermal system.经皮给药系统应用后尼古丁的生物利用度及吸收动力学
Br J Clin Pharmacol. 1993 Sep;36(3):221-7. doi: 10.1111/j.1365-2125.1993.tb04221.x.
10
Heating and cooling of the nitroglycerin patch application area modify the plasma level of nitroglycerin.硝酸甘油贴片敷用部位的加热和冷却会改变硝酸甘油的血浆水平。
Eur J Clin Pharmacol. 1992;43(6):625-8. doi: 10.1007/BF02284961.
引用本文的文献
1
An anti-doping perspective on nicotine detection in the peri-exercise period in a cohort of trained male cyclists.对一组训练有素的男性自行车运动员运动期间尼古丁检测的反兴奋剂视角
Curr Res Physiol. 2020 May 1;2:30-33. doi: 10.1016/j.crphys.2020.04.001. eCollection 2020 Jun.
2
Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients In Vivo and In Vitro.体内和体外暴露于温度梯度时皮肤和透皮给药系统中的温度分布特征
Pharm Res. 2017 Jul;34(7):1491-1504. doi: 10.1007/s11095-017-2171-x. Epub 2017 May 10.
3
Heat effects on drug delivery across human skin.热对药物透过人体皮肤传递的影响。
Expert Opin Drug Deliv. 2016;13(5):755-68. doi: 10.1517/17425247.2016.1136286. Epub 2016 Jan 25.
4
The effect of acute exercise on cigarette cravings while using a nicotine lozenge.在使用尼古丁含片时急性运动对烟瘾的影响。
Psychopharmacology (Berl). 2015 Jul;232(14):2531-9. doi: 10.1007/s00213-015-3887-0. Epub 2015 Feb 22.
5
Transdermal patch drug delivery interactions with exercise.经皮贴片药物传递与运动的相互作用。
Sports Med. 2011 Mar 1;41(3):177-83. doi: 10.2165/11586080-000000000-00000.
6
Clinical pharmacokinetics and pharmacodynamics of glyceryl trinitrate and its metabolites.硝酸甘油及其代谢产物的临床药代动力学和药效学
Clin Pharmacokinet. 2003;42(3):205-21. doi: 10.2165/00003088-200342030-00001.
本文引用的文献
1
Transdermal nicotine in smoking cessation. A meta-analysis.经皮尼古丁用于戒烟：一项荟萃分析。
Eur J Clin Pharmacol. 1993;45(6):519-28. doi: 10.1007/BF00315308.
2
Nicotine in hair of smokers and non-smokers: sampling procedure and gas chromatographic/mass spectrometric analysis.吸烟者与非吸烟者头发中的尼古丁：采样程序及气相色谱/质谱分析
Pharmacol Toxicol. 1994 Sep-Oct;75(3-4):143-9. doi: 10.1111/j.1600-0773.1994.tb00337.x.
3
Effect of nicotine on the enterochromaffin like cells of the oxyntic mucosa of the rat.尼古丁对大鼠胃黏膜嗜铬样细胞的影响。
Life Sci. 1993;53(1):21-9. doi: 10.1016/0024-3205(93)90607-5.
4
Increased uptake of transdermal glyceryl trinitrate during physical exercise and during high ambient temperature.在体育锻炼期间以及环境温度较高时，经皮吸收的硝酸甘油摄取量增加。
Am Heart J. 1986 Sep;112(3):537-41. doi: 10.1016/0002-8703(86)90518-1.
5
Principles of transdermal nitroglycerin administration.经皮硝酸甘油给药的原则。
Eur Heart J. 1989 May;10 Suppl A:26-9. doi: 10.1093/eurheartj/10.suppl_a.26.
6
The promise of transdermal drug delivery.经皮给药的前景。
Br J Anaesth. 1990 Jan;64(1):7-10. doi: 10.1093/bja/64.1.7.
7
Stable isotope method for studying transdermal drug absorption: the nicotine patch.用于研究透皮药物吸收的稳定同位素法：尼古丁贴片
Clin Pharmacol Ther. 1991 Sep;50(3):286-93. doi: 10.1038/clpt.1991.138.
8
Transdermal nitrate therapy: bioavailability during exercise increases transiently after the daily change of patch.经皮硝酸酯类药物治疗：在每日更换贴片后，运动期间的生物利用度会短暂增加。
Br J Clin Pharmacol. 1991 May;31(5):560-2. doi: 10.1111/j.1365-2125.1991.tb05582.x.
9
Intravenous nicotine retards transdermal absorption of nicotine: evidence of blood flow--limited percutaneous absorption.静脉注射尼古丁会延缓尼古丁的经皮吸收：血流限制经皮吸收的证据。
Clin Pharmacol Ther. 1992 Sep;52(3):223-30. doi: 10.1038/clpt.1992.134.
10
Heating and cooling of the nitroglycerin patch application area modify the plasma level of nitroglycerin.硝酸甘油贴片敷用部位的加热和冷却会改变硝酸甘油的血浆水平。
Eur J Clin Pharmacol. 1992;43(6):625-8. doi: 10.1007/BF02284961.
Zotero 插件