Williams T J, Salamonsen R F, Snell G, Kaye D, Esmore D S
Department of Respiratory Medicine, Alfred Hospital, Melbourne, Australia.
J Heart Lung Transplant. 1995 May-Jun;14(3):419-23.
Substantial interest has developed in the physiologic and therapeutic role of nitric oxide in the last few years. In patients with pulmonary hypertension it appears to be a useful selective pulmonary vasodilator; however, many issues of both staff and patient safety remained unanswered.
This study examines further safety issues and also presents preliminary clinical experience in patients after orthotopic heart transplantation with pulmonary hypertension and right-sided ventricular failure.
Atmospheric levels of nitric oxide and nitrogen dioxide are 100 times less than occupational health standards. When nitric oxide is used at 70 parts per million in the presence of a fraction of inspired oxygen greater than 0.60, nitrogen dioxide levels in the circuit exceed the published short-term exposure limit of the American Conference of Government Industrial Hygienist of 5 parts per million.
Staff safety appears confirmed, but despite encouraging clinical results, further longer term safety and efficacy studies are indicated.
在过去几年中，人们对一氧化氮的生理和治疗作用产生了浓厚兴趣。在肺动脉高压患者中，它似乎是一种有用的选择性肺血管扩张剂；然而，许多关于工作人员和患者安全的问题仍未得到解答。
本研究进一步探讨了安全问题，并介绍了原位心脏移植后合并肺动脉高压和右心室衰竭患者的初步临床经验。
大气中的一氧化氮和二氧化氮水平比职业健康标准低100倍。当在吸入氧分数大于0.60的情况下以百万分之70的浓度使用一氧化氮时，回路中的二氧化氮水平超过了美国政府工业卫生学家会议公布的百万分之5的短期暴露限值。
工作人员的安全似乎得到了证实，但尽管临床结果令人鼓舞，但仍需进行进一步的长期安全性和有效性研究。
