[兔小肠黏膜中Na⁺/HCO₃⁻（Cl⁻）刺激的ATP酶的特性]
[Properties of Na+/HCO3-(Cl-)-stimulated ATPase in rabbit small intestinal mucosa].
作者信息
Shubin V S, Iurkiv V A
出版信息
Biokhimiia. 1995 Jun;60(6):864-73.
It has been demonstrated that histamine induces in rabbit small intestine an ATPase activity which is stimulated by NaCl or NaHCO3. The Na+/HCO3- (C1-)-stimulated ATPase activity, unlike the Mg2+,HCO3(-)-ATPase activity, has a pH optimum at pH 6.2, is inhibited by ethacrynic acid (10(-4) M) and bivalent metal ions (but not 10(-2) M thiocyanate). The substrate specificity of Na+/HCO3- (C1-)-ATPase and its regulation by Ca2+ ions has been studied. The feasible role of the enzyme in secretion is discussed.
已经证明，组胺可诱导兔小肠产生一种ATP酶活性，该活性可被NaCl或NaHCO₃刺激。与Mg²⁺、HCO₃⁻-ATP酶活性不同，Na⁺/HCO₃⁻（Cl⁻）刺激的ATP酶活性在pH 6.2时具有最佳pH值，可被依他尼酸（10⁻⁴M）和二价金属离子（但不是10⁻²M硫氰酸盐）抑制。研究了Na⁺/HCO₃⁻（Cl⁻）-ATP酶的底物特异性及其受Ca²⁺离子的调节。讨论了该酶在分泌中的可能作用。
Zotero 插件