Hettlich H J, Lucke K, Asiyo-Vogel M, Vogel A
Klinik für Augenheilkunde, Medizinische Universität zu Lübeck.
Ophthalmologe. 1995 Jun;92(3):329-34.
Various experimental lens refilling procedures have been proposed. One of these methods uses endocapsular polymerization of the injected material by light exposure. In this study we wanted to characterize the potential risks of this procedure due to light and temperature hazards. We performed in vitro experiments on enucleated pig eyes and an in vivo study on 15 rabbits. During the polymerization process the highest temperature recorded (45.1 degrees C) was measured at the posterior lens capsule for a few seconds. The measured irradiance (0.065 W/cm2) and the risk of photochemical damage to the retina during 20 s of polymerization was comparable to that caused by 1.5 min of standard coaxial illumination with our operating microscope. In vivo we found no serious inflammatory reactions except for four cases where surgical problems had occurred. No direct retinal damage could be detected histopathologically. In conclusion, we think that lens refilling and endocapsular polymerization are promising techniques. However, refilling materials with better physical properties than those available so far need to be developed.
人们已经提出了各种实验性的晶状体填充方法。其中一种方法是通过光照使注入的材料在囊袋内发生聚合反应。在本研究中，我们想要了解由于光照和温度危害而导致的该操作潜在风险。我们对摘除的猪眼进行了体外实验，并对15只兔子进行了体内研究。在聚合过程中，后囊膜处记录到的最高温度（45.1摄氏度）持续了几秒。在聚合反应20秒期间测得的辐照度（0.065瓦/平方厘米）以及视网膜发生光化学损伤的风险，与我们的手术显微镜进行1.5分钟标准同轴照明所造成的相当。在体内实验中，除了4例出现手术问题的情况外，我们未发现严重的炎症反应。组织病理学检查未发现直接的视网膜损伤。总之，我们认为晶状体填充和囊袋内聚合是很有前景的技术。然而，需要开发出物理性能比目前可用材料更好的填充材料。
