Kwon Ji Won, Han Young Keun, Lee Woo Jin, Cho Chong Su, Paik Seung Joon, Cho Dong Il, Lee Jin Hak, Wee Won Ryang
Department of Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Korea.
J Cataract Refract Surg. 2005 Mar;31(3):607-13. doi: 10.1016/j.jcrs.2004.05.051.
To induce irreversible gelation of poloxamer, a thermosensitive polymer hydrogel, by using a photoinitiator and ultraviolet (UV) irradiation and to verify the biocompatibility and use of poloxamer as an injectable intraocular lens (IOL) material.
Department of Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
In 10 rabbits, endocapsular phacoemulsification was performed and a poloxamer-photoinitiator mixture was injected into the capsular bag through a small capsulorhexis site. In 1 eye, the capsulorhexis site was closed with a small plug and the entire eye was irradiated with UV light for 5 minutes. Postoperatively, poloxamer transparency and effect on the conjunctiva, cornea, iris, vitreous, and retina were observed.
A mixture comprising 25% poloxamer and 0.01% photoinitiator produced a poloxamer that remained transparent in the lens capsule for up to 6 months. No inflammatory response or toxicity was observed in the conjunctiva, cornea, iris, vitreous, or retina.
Poloxamer is a potentially suitable material for an injectable IOL. Further study is needed.
通过使用光引发剂和紫外线（UV）照射诱导热敏性聚合物水凝胶泊洛沙姆发生不可逆凝胶化，并验证泊洛沙姆作为可注射人工晶状体（IOL）材料的生物相容性及用途。
韩国首尔国立大学医学院眼科、首尔人工眼中心、首尔国立大学医院临床研究所。
对10只兔子进行囊内超声乳化，并通过小的连续环形撕囊口将泊洛沙姆 - 光引发剂混合物注入囊袋内。在1只眼中，用小塞子封闭连续环形撕囊口，并用紫外线对整个眼睛照射5分钟。术后观察泊洛沙姆的透明度以及对结膜、角膜、虹膜、玻璃体和视网膜的影响。
包含25%泊洛沙姆和0.01%光引发剂的混合物产生的泊洛沙姆在晶状体囊内可保持透明长达6个月。在结膜、角膜、虹膜、玻璃体或视网膜中未观察到炎症反应或毒性。
泊洛沙姆是一种潜在适用于可注射人工晶状体的材料。尚需进一步研究。
