黄精对Wistar肥胖大鼠血糖及葡萄糖转运蛋白2（GLUT2）mRNA表达的影响。

Effect of polygonati rhizoma on blood glucose and facilitative glucose transporter isoform 2 (GLUT2) mRNA expression in Wistar fatty rats.

作者信息

Miura T, Kato A, Usami M, Kadowaki S, Seino Y

机构信息

Department of Clinical Nutrition, Suzuka University of Medical Science and Technology, Faculty of Health Science, Mie, Japan.

出版信息

Biol Pharm Bull. 1995 Apr;18(4):624-5. doi: 10.1248/bpb.18.624.

DOI:10.1248/bpb.18.624

PMID:7655441

Abstract

The intraperitoneal administration of the methanol extract of Polygonati Rhizoma (OM) to Wistar fatty rats caused a significant decrease in the blood glucose level 4h after its administration at 800 mg/kg (p < 0.01). The hepatic content of facilitative glucose transporter isoform 2, liver type glucose transporter (GLUT2) mRNA content from rat liver significantly decreased in the intraperitoneally OM-treated rats compared to that in the controls (p < 0.01). These results suggest that the hypoglycemic effect of OM is presumably due, at least in part, to the reduction of GLUT2 mRNA expression. Because of this unique therapeutic mechanism, OM could be a new category of therapeutic agent for non-insulin-dependent diabetes mellitus.

摘要

对Wistar肥胖大鼠腹腔注射黄精甲醇提取物（OM），在以800mg/kg剂量给药4小时后，血糖水平显著降低（p<0.01）。与对照组相比，腹腔注射OM的大鼠肝脏中促进性葡萄糖转运蛋白异构体2（肝脏型葡萄糖转运蛋白，GLUT2）的mRNA含量显著降低（p<0.01）。这些结果表明，OM的降血糖作用可能至少部分归因于GLUT2 mRNA表达的降低。由于这种独特的治疗机制，OM可能成为治疗非胰岛素依赖型糖尿病的新型治疗药物。