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[霍乱弧菌对诊断噬菌体耐药的原因]

[The reasons for the resistance of Vibrio cholerae to diagnostic phages].

作者信息

Kudriakova T A, Cherepakhina I Ia, Alekseeva L P, Makedonova L D, Evteeva E I, Dudkina O V, Burlakova O S, Vlasov V P, Gavrilov B V, Vodop'ianov S O

出版信息

Mikrobiol Z. 1995 May-Jun;57(3):56-64.

PMID:7655658
Abstract

Phage resistance of 225 strains of cholera germs of O1 group obtained from different countries in 1988-1992 has been analyzed. Change of sensitivity to diagnostic phages was mostly connected with the decrease or loss of agglutinability in cholera sera. Phage resistance is rather conditioned by the change of the surface structures of the cell and by further change of phage reception zones. The increase in the number of strains sensitive to diagnostic phages after 6-12 months of storage evidenced for stabilization of cell wall structures and increase of their viability under relatively favourable conditions of storage.

摘要

对1988 - 1992年从不同国家获得的225株O1群霍乱菌的噬菌体抗性进行了分析。对诊断噬菌体敏感性的变化大多与霍乱血清中凝集性的降低或丧失有关。噬菌体抗性相当程度上取决于细胞表面结构的变化以及噬菌体受体区域的进一步改变。在储存6 - 12个月后,对诊断噬菌体敏感的菌株数量增加,这证明了细胞壁结构的稳定以及在相对有利的储存条件下其活力的增强。

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