替诺昔康对健康志愿者中甲苯磺丁脲药代动力学及血糖浓度的影响。
The effect of tenoxicam on tolbutamide pharmacokinetics and glucose concentrations in healthy volunteers.
作者信息
Day R O, Geisslinger G, Paull P, Williams K M
机构信息
Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital Sydney, Australia.
出版信息
Int J Clin Pharmacol Ther. 1995 May;33(5):308-10.
PMID:7655772
Abstract
There was no significant difference in the pharmacokinetic parameters of tolbutamide (500 mg) determined before and after 14 days treatment with tenoxicam (20 mg/day) in 7 healthy volunteers (6 male, 1 female). In addition, co-administration of tenoxicam did not alter blood glucose concentrations.
摘要
在7名健康志愿者（6名男性，1名女性）中，用替诺昔康（20毫克/天）治疗14天前后测定的甲苯磺丁脲（500毫克）的药代动力学参数没有显著差异。此外，替诺昔康的联合给药并未改变血糖浓度。
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