Calissendorff B M, Lönnqvist B, el Azazi M
Department of Ophthalmology, St Erik's Eye Hospital, Stockholm, Sweden.
Acta Ophthalmol Scand. 1995 Apr;73(2):152-4. doi: 10.1111/j.1600-0420.1995.tb00657.x.
In a prospective study, adult patients treated with bone marrow transplantation were examined with respect to cataract development. There were 99 patients with a survival of at least one year. Ten of them had aplastic anemia and the rest had various hematological malignancies. Mean follow-up time was 3.9 years (range 1-10). All in the hematological malignancies group but none in the aplastic anemia group, were conditioned with irradiation. Cytostatic drugs were administered in all cases. Depending on the type of disease and its reaction to bone marrow transplantation, steroid treatment was sometimes indicated. Cataract did not occur in any of the 10 patients treated for aplastic anemia, whereas all patients with hematological malignancies had developed cataract after 4 years' observation. Most patients in the hematological malignancies group already showed lens opacifications after 2 years. Cataract surgery on the first eye was performed in 39 cases, a median of 3.7 years after bone marrow transplantation. Cataract development was clearly correlated to radiation. No relationship was found to other conditioning treatments, although a synergistic effect is possible.
在一项前瞻性研究中，对接受骨髓移植治疗的成年患者进行了白内障发生情况的检查。有99例患者存活至少一年。其中10例患有再生障碍性贫血，其余患者患有各种血液系统恶性肿瘤。平均随访时间为3.9年（范围1 - 10年）。血液系统恶性肿瘤组的所有患者均接受了放疗，而再生障碍性贫血组无一例接受放疗。所有病例均使用了细胞毒性药物。根据疾病类型及其对骨髓移植的反应，有时需要进行类固醇治疗。接受再生障碍性贫血治疗的10例患者中无一例发生白内障，而所有血液系统恶性肿瘤患者在观察4年后均发生了白内障。血液系统恶性肿瘤组的大多数患者在2年后就已出现晶状体混浊。39例患者在骨髓移植后中位数3.7年时对第一只眼进行了白内障手术。白内障的发生与放疗明显相关。未发现与其他预处理治疗存在关联，不过可能存在协同效应。
