Calissendorff B M, Bolme P
Department of Ophthalmology, Karolinska Institute, St Erik's Eye Hospital, Stockholm, Sweden.
Br J Ophthalmol. 1993 Jan;77(1):36-8. doi: 10.1136/bjo.77.1.36.
Cataract development in bone marrow transplanted (BMT) patients was studied prospectively. There were 61 children, transplanted before the age of 18 years, who survived more than 1 year after transplantation. Patients transplanted for leukaemia (n = 43) were conditioned before BMT with cyclophosphamide (Cy) and total body irradiation (TBI). Patients with severe aplastic anaemia (SAA) (n = 9) only received Cy. None of the patients with SAA developed cataracts. All children with leukaemia, who were followed for at least 3 years (n = 37), developed lens posterior subcapsular cataracts (PSC). Cataract extraction was performed in 28 eyes, on average 5.1 years (range 3-9 years) after BMT. Postoperative corrected visual acuity was similar to that before BMT. The majority of cases needed laser capsulotomy within 2 years after cataract extraction. TBI seems to be the main cause for the high incidence of cataract after BMT. A relationship to steroid administration could not be proved, but a contributory effect is not excluded.
对骨髓移植（BMT）患者的白内障发展情况进行了前瞻性研究。有61名18岁前接受移植且移植后存活超过1年的儿童。因白血病接受移植的患者（n = 43）在BMT前接受了环磷酰胺（Cy）和全身照射（TBI）预处理。严重再生障碍性贫血（SAA）患者（n = 9）仅接受了Cy。SAA患者均未发生白内障。所有随访至少3年的白血病患儿（n = 37）均发生了晶状体后囊下白内障（PSC）。28只眼进行了白内障摘除，平均在BMT后5.1年（范围3 - 9年）。术后矫正视力与BMT前相似。大多数病例在白内障摘除后2年内需要进行激光囊切开术。TBI似乎是BMT后白内障高发的主要原因。虽然无法证实与类固醇给药有关，但不排除有促成作用。
