Kwong Y L, Wong K F
University Department of Medicine, Queen Mary Hospital, Hong Kong.
Cancer Genet Cytogenet. 1995 Aug;83(1):1-4. doi: 10.1016/s0165-4608(95)00027-5.
Hyperdiploidy is a rare finding in acute myeloid leukemia (AML), and the cases described so far showed characteristic large and bizarre blasts. We further demonstrate this morphologic/karyotypic relationship in a case of hyperdiploid AML by fluorescence in situ hybridization. Together with previous observations, we propose that in myeloid leukemias, increase in DNA content is accompanied by a corresponding increase in blast size. If large and bizarre blasts are shown on morphologic analysis, polyploid metaphases on cytogenetic preparations should also be analyzed, as they may be derived from these cells.
超二倍体在急性髓系白血病（AML）中是一种罕见的发现，迄今为止所描述的病例显示出特征性的大而怪异的原始细胞。我们通过荧光原位杂交在一例超二倍体AML病例中进一步证明了这种形态学/核型关系。结合先前的观察结果，我们提出在髓系白血病中，DNA含量的增加伴随着原始细胞大小的相应增加。如果形态学分析显示有大而怪异的原始细胞，那么细胞遗传学制片上的多倍体中期相也应进行分析，因为它们可能来源于这些细胞。
