Khokhar M T, Brito-Babapulle V, Matutes E, Catovsky D
Academic Department of Hematology and Cytogenetics, Royal Marsden Hospital, Sutton, U.K.
Cancer Genet Cytogenet. 1995 Aug;83(1):18-24. doi: 10.1016/s0165-4608(94)00308-4.
We have carried out chromosome analysis in a series of 16 non-Hodgkin Lymphoma (NHL) cases in leukemic phase. The diagnoses in these patients based on histology and immunologic markers were as follows: follicular lymphoma (FL), 3 cases; mantle cell lymphoma (Mc), 4 cases; lymphoplasmacytic lymphoma (LPL), 8 cases, and large cell lymphoma, 1 case. We have shown that the t(14;18), t(11;14), and trisomy 12 retained their subtype association with FL, Mc, and LPL, respectively, as in their nonleukemic counterparts with one case of FL showing t(1;19)(q23;p13). Among the four LPL cases without trisomy 12, one case each showed t(12;14)(q13;q32), trisomy 14, t(1;3)(p34;q21), and del(3)(q21). The t(1;19) and t(12;14) may represent rare events in FL and LPL, respectively, and may be uniquely associated with the leukemic phase. The breakpoint 14q32 was the most common single breakpoint involved, sometimes involving both chromosome 14 homologues depicting its association with primary and secondary genetic events in the disease progression. In addition to the main abnormalities, we have shown additional complex abnormalities in 14 of 16 cases. Among these, chromosome 3 was the most commonly involved, affecting the short or long arm or the whole chromosome; 5 of the 16 cases involved breakpoint 3q21. The high incidence of additional abnormalities in these NHL in leukemic phase suggest an association with the development of leukemia and progression of the disease.
我们对16例处于白血病期的非霍奇金淋巴瘤（NHL）患者进行了染色体分析。根据组织学和免疫标志物对这些患者的诊断如下：滤泡性淋巴瘤（FL）3例；套细胞淋巴瘤（Mc）4例；淋巴浆细胞淋巴瘤（LPL）8例，大细胞淋巴瘤1例。我们发现，t(14;18)、t(11;14)和12号染色体三体分别与FL、Mc和LPL保持其亚型相关性，与它们的非白血病对应物情况相同，其中1例FL显示t(1;19)(q23;p13)。在4例无12号染色体三体的LPL病例中，各有1例显示t(12;14)(q13;q32)、14号染色体三体、t(1;3)(p34;q21)和del(3)(q21)。t(1;19)和t(12;14)可能分别代表FL和LPL中的罕见事件，且可能与白血病期独特相关。14q32断点是最常见的单个受累断点，有时涉及14号染色体的两个同源染色体，表明其与疾病进展中的原发性和继发性遗传事件相关。除了主要异常外，我们还在16例中的14例中发现了其他复杂异常。其中，3号染色体是最常受累的，影响短臂或长臂或整个染色体；16例中有5例涉及3q21断点。这些处于白血病期的NHL中额外异常的高发生率表明其与白血病的发生和疾病进展相关。
