单萜紫苏醇诱导神经2A细胞分化

Induction of differentiation in neuro-2A cells by the monoterpene perillyl alcohol.

作者信息

Shi W, Gould M N

机构信息

University of Wisconsin-Madison, Department of Human Oncology 53792, USA.

出版信息

Cancer Lett. 1995 Aug 16;95(1-2):1-6. doi: 10.1016/0304-3835(95)03859-u.

DOI:10.1016/0304-3835(95)03859-u

PMID:7656215

Abstract

The monoterpenes limonene and perillyl alcohol have been shown to induce the complete regression of rat mammary carcinomas by what appears to be a cytostatic and differentiation process. In order to evaluate the differentiating effects of the monoterpenes we tested the ability of perillyl alcohol to induce differentiation in a well-characterized neuroblastoma cell model. Perillyl alcohol was found to be a potent inducer of the neuroblastoma-derived cell line Neuro-2A. Several cellular effects of monoterpenes were ruled out as contributing to Neuro-2A differentiation including its cytostatic effect and its ability to inhibit ubiquinone (CoQ) syntheses.

摘要

单萜类化合物柠檬烯和紫苏醇已被证明可通过一种似乎是细胞抑制和分化的过程诱导大鼠乳腺癌完全消退。为了评估单萜类化合物的分化作用，我们在一个特征明确的神经母细胞瘤细胞模型中测试了紫苏醇诱导分化的能力。发现紫苏醇是神经母细胞瘤衍生细胞系Neuro-2A的有效诱导剂。单萜类化合物的几种细胞效应被排除与Neuro-2A分化有关，包括其细胞抑制作用和抑制泛醌（CoQ）合成的能力。