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单萜紫苏醇对泛醌和胆固醇合成的抑制作用。

Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol.

作者信息

Ren Z, Gould M N

机构信息

Department of Human Oncology, University of Wisconsin-Madison 53792.

出版信息

Cancer Lett. 1994 Jan 30;76(2-3):185-90. doi: 10.1016/0304-3835(94)90396-4.

Abstract

Monoterpenes such as perillyl alcohol have been shown to cause the complete regression of advanced mammary carcinomas. Given the common origin of plant monoterpenes and many important molecules in mammalian mevalonate metabolism pathway, we investigated the effects of the monoterpene perillyl alcohol on mevalonate metabolism. NIH3T3 cells were labeled with [14C]mevalonolactone and lipids were analyzed. Perillyl alcohol inhibited ubiquinone synthesis and blocked the conversion of lathosterol to cholesterol. These two cellular effects of perillyl alcohol may contribute to the antitumor activity of the monoterpenes.

摘要

诸如紫苏醇之类的单萜已被证明可使晚期乳腺癌完全消退。鉴于植物单萜与哺乳动物甲羟戊酸代谢途径中许多重要分子的共同起源,我们研究了单萜紫苏醇对甲羟戊酸代谢的影响。用[14C]甲羟戊酸内酯标记NIH3T3细胞并分析脂质。紫苏醇抑制辅酶Q的合成并阻断羊毛甾醇向胆固醇的转化。紫苏醇的这两种细胞效应可能有助于单萜的抗肿瘤活性。

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