Hilkens P H, van der Burg M E, Moll J W, van den Bent M J, van Putten W L, Vecht C J
Department of Neuro-Oncology, Dr. Daniel den Hoed Cancer Center and University Hospital, Rotterdam, Netherlands.
Clin Neurol Neurosurg. 1995 May;97(2):139-41. doi: 10.1016/0303-8467(95)00023-d.
The efficacy of Org 2766, an ACTH(4-9) analogue, on the recovery of cisplatin neuropathy of longstanding duration was investigated in a phase II study. Twenty-two patients were treated with Org 2766 during a period of 4 months and vibration perception threshold (VPT) and sum scores for neuropathic symptoms and signs were compared with pre-treatment values. No change in VPT could be detected. Although there was a small improvement of clinical measures for neuropathy, no clear evidence for repair could be obtained. These results indicate no beneficial effect of Org 2766 on recovery of a longstanding cisplatin neuropathy.
