Wolterink G, Bouwman T R, Eenink M J, De Nijs H, van Ree J M
Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, The Netherlands.
J Pharm Pharmacol. 1990 Jul;42(7):508-10. doi: 10.1111/j.2042-7158.1990.tb06607.x.
The functional recovery from impaired motor activity induced by 6-hydroxydopamine lesions in rat nucleus accumbens was accelerated by subcutaneous treatment with the ACTH-(4-9) analogue Met/O2/-Glu-His-Phe-D-Lys-Phe (ORG 2766). Treatment was effective after daily injections of ORG 2766 dissolved in saline during the first 6 days following the lesion (ED50: 28.5 ng kg-1 day-1) or after a single injection of the peptide in a biodegradable microsphere formulation administered after the lesion (ED50: 8.9 ng kg-1 day-1). This study shows that a single injection of a microsphere preparation can replace multiple injections with ORG 2766 in order to facilitate functional recovery after brain damage.
皮下注射促肾上腺皮质激素（4-9）类似物Met/O2/-Glu-His-Phe-D-Lys-Phe（ORG 2766）可加速大鼠伏隔核6-羟基多巴胺损伤所致运动功能障碍的功能恢复。在损伤后的前6天，每天注射溶解于生理盐水中的ORG 2766（半数有效剂量：28.5 ng kg-1 天-1），或在损伤后注射一次可生物降解微球制剂中的该肽（半数有效剂量：8.9 ng kg-1 天-1），治疗均有效。本研究表明，单次注射微球制剂可替代多次注射ORG 2766，以促进脑损伤后的功能恢复。
