Boutin C, Rey F, Viallat J R
Department of Pulmonology, Hopital de la Conception, Marseille, France.
Chest. 1995 Sep;108(3):754-8. doi: 10.1378/chest.108.3.754.
The purpose of this randomized prospective study was to assess the efficacy of local radiotherapy in preventing malignant seeding along invasive diagnostic procedures (cytology, needle biopsy, thoracoscopy, or chest tube placement) in patients with malignant pleural mesothelioma. Forty consecutive patients with histologically proven malignant mesothelioma were enrolled. Twenty patients received three daily sessions of radiotherapy at a dosage of 7 Gy 10 to 15 days after thoracoscopy. The other 20 patients did not receive radiotherapy. None of the 20 patients treated developed entry tract metastasis. In contrast, 8 of the 20 (40%) patients who were not treated developed metastases. These findings confirm the efficacy and safety of early local radiotherapy in preventing malignant seeding after invasive diagnostic procedures in patients with malignant pleural mesothelioma.
这项随机前瞻性研究的目的是评估局部放疗在预防恶性胸膜间皮瘤患者经侵入性诊断操作（细胞学检查、针吸活检、胸腔镜检查或胸腔置管）后发生肿瘤种植转移方面的疗效。连续纳入40例经组织学证实为恶性间皮瘤的患者。20例患者在胸腔镜检查后10至15天接受每日3次、每次剂量为7 Gy的放疗。另外20例患者未接受放疗。接受治疗的20例患者均未发生穿刺通道转移。相比之下，未接受治疗的20例患者中有8例（40%）发生了转移。这些结果证实了早期局部放疗在预防恶性胸膜间皮瘤患者经侵入性诊断操作后发生肿瘤种植转移方面的疗效和安全性。
