[The expressions of proliferating cell nuclear antigen (PCNA) in primary gallbladder carcinoma and its significance].

Anti-PCNA monoclonal antibody and ABC staining were used to study the expressions of proliferating cell nuclear antigen/cyclin in patients with primary gallbladder carcinoma (31 cases), adenoma and tumor-like lesions of gallbladder (10 cases), and chronic cholecystitis (7 cases). The PCNA indices were 373.48 +/- 219.83, 94.9 +/- 93, and 56 +/- 28.63, respectively. This index was significantly higher in malignant lesions than in benign diseases (P < 0.01). There was a tendency that the higher the PCNA index, the lower differential degree of the gallbladder carcinoma (P < 0.01). But there were no significant correlations between the PCNA indices and the pathohistological types, the nevin classifications and the TNM classifications of the gallbladder carcinoma (P > 0.05).