Qing D, Xia L, Zhang X
Affiliated Hospital of Guiyang Medical College.
Zhonghua Wai Ke Za Zhi. 1995 Feb;33(2):102-4.
Anti-PCNA monoclonal antibody and ABC staining were used to study the expressions of proliferating cell nuclear antigen/cyclin in patients with primary gallbladder carcinoma (31 cases), adenoma and tumor-like lesions of gallbladder (10 cases), and chronic cholecystitis (7 cases). The PCNA indices were 373.48 +/- 219.83, 94.9 +/- 93, and 56 +/- 28.63, respectively. This index was significantly higher in malignant lesions than in benign diseases (P < 0.01). There was a tendency that the higher the PCNA index, the lower differential degree of the gallbladder carcinoma (P < 0.01). But there were no significant correlations between the PCNA indices and the pathohistological types, the nevin classifications and the TNM classifications of the gallbladder carcinoma (P > 0.05).
采用抗增殖细胞核抗原（PCNA）单克隆抗体及ABC染色法，对31例原发性胆囊癌、10例胆囊腺瘤及肿瘤样病变和7例慢性胆囊炎患者进行增殖细胞核抗原/细胞周期蛋白表达的研究。PCNA指数分别为373.48±219.83、94.9±93和56±28.63。该指数在恶性病变中显著高于良性疾病（P<0.01）。有PCNA指数越高，胆囊癌分化程度越低的趋势（P<0.01）。但PCNA指数与胆囊癌的病理组织学类型、Nevin分期及TNM分期之间无显著相关性（P>0.05）。
