[The expression and significance of proliferating cell nuclear antigen/cyclin in cholangiocarcinoma and gallbladder carcinoma].

The expressions and significance of proliferating cell nuclear antigen (PCNA) were studied by immunohistochemical method in 40 cases of gallbladder carcinoma and 42 cases of cholangiocarcinoma. The counting score of positive cells was significantly lower in cases of well-differentiation, histologic grade I and without metastasis than that in cases of poor-differentiation, histologic grade III and with metastasis. Close correlations were found between the survival time and the counting score of PCNA. These results suggested the cholangiocarcinoma and gallbladder carcinoma with highly positive cell rate might have poor prognosis, and PCNA might be an important marker reflecting the biological behavior and having prognostic value.