Li D, Zhang X, Song Y
Department of Digestive Medicine, Second Teaching Hospital, Bethune University of Medical Sciences, Changchun.
Zhonghua Zhong Liu Za Zhi. 1995 Mar;17(2):152-5.
In 16 patients with lung cancer tumor infiltrating Lymphocytes (TIL) and peripheral blood lymphocytes (PBL) and their antitumor activities after IL-2 activation and were tested by 3H-TdR releasing assay. The results showed that the cytolytic activity of TIL against autologous tumor cells was lower than of IL-2 activated PBL (LAK cells) at the early incubation period but become markedly higher than that of LAK cells when the incubation lasted for 20 to 25 days. The subjectively most patients received systemic TIL treatment felt better and their immune functions were improved. Transiant Low-grade fever occurred in cases and drop of arterial blood pressure in 1. No potentially fatal toxic effect was observed.
对16例肺癌患者的肿瘤浸润淋巴细胞（TIL）和外周血淋巴细胞（PBL）及其经白细胞介素-2（IL-2）激活后的抗肿瘤活性进行了检测，采用3H-胸腺嘧啶核苷（3H-TdR）释放试验。结果显示，在培养初期，TIL对自体肿瘤细胞的细胞溶解活性低于IL-2激活的PBL（淋巴因子激活的杀伤细胞，LAK细胞），但当培养持续20至25天时，其活性显著高于LAK细胞。主观上，大多数接受全身TIL治疗的患者感觉好转，免疫功能得到改善。部分病例出现短暂低热，1例出现动脉血压下降。未观察到潜在的致命毒性作用。
