Haby M M, Peat J K, Mellis C M, Anderson S D, Woolcock A J
Dept of Medicine, University of Sydney, Australia.
Eur Respir J. 1995 May;8(5):729-36.
We assessed the validity, repeatability and practicality of a standardized exercise challenge protocol for measuring airway responsiveness in epidemiological studies of asthma in children aged 8-11 yrs. The construct validity of the exercise challenge was assessed by comparing response to exercise with other measures of asthma, i.e. wheeze frequency, diagnosed asthma, asthma medication use, atopy and urgent doctor visits (n = 802), and by comparison with response to histamine challenge (n = 201). Repeatability was assessed by comparison of responsiveness to two exercise challenges within 3 days (n = 113), and practicality was assessed by measurement of consent, compliance and throughput rates (n = 802). There was a significant relationship between frequency of wheeze attacks and % fall in forced expiratory volume in one second (FEV1) to exercise. The correlation (r) between % fall in FEV1 to exercise challenge and dose-response ratio to histamine challenge was 0.59. The repeatability of the exercise challenge was +/- 12% fall in FEV1. Consent and compliance rates for exercise challenge were 78 and 99%, respectively, and the mean throughput rate was 45 children per school day for a team of seven researchers. In conclusion, this exercise challenge was found to have good validity and to be reliable and practical. Thus, this challenge could be used as a standardized epidemiological tool to investigate the prevalence, aetiology and mechanisms of asthma.
我们评估了一种标准化运动激发试验方案在8至11岁儿童哮喘流行病学研究中测量气道反应性的有效性、可重复性和实用性。通过将运动激发试验的反应与哮喘的其他指标（即喘息频率、确诊哮喘、哮喘药物使用、特应性和紧急就医情况，n = 802）进行比较，以及与组胺激发试验的反应进行比较（n = 201），来评估运动激发试验的结构效度。通过比较3天内两次运动激发试验的反应性（n = 113）来评估可重复性，并通过测量同意率、依从率和通量率（n = 802）来评估实用性。喘息发作频率与一秒用力呼气容积（FEV1）运动后下降百分比之间存在显著关系。运动激发试验中FEV1下降百分比与组胺激发试验剂量反应比之间的相关性（r）为0.59。运动激发试验的可重复性为FEV1下降±12%。运动激发试验的同意率和依从率分别为78%和99%，对于一个由七名研究人员组成的团队，平均通量率为每个教学日45名儿童。总之，发现这种运动激发试验具有良好的效度，并且可靠且实用。因此，这种激发试验可作为一种标准化的流行病学工具，用于研究哮喘的患病率、病因和机制。
