Haby M M, Anderson S D, Peat J K, Mellis C M, Toelle B G, Woolcock A J
Department of Medicine, University of Sydney, Australia.
Eur Respir J. 1994 Jan;7(1):43-9. doi: 10.1183/09031936.94.07010043.
We investigated whether an exercise challenge protocol is suitable for measuring bronchial responsiveness in epidemiological studies of asthma in children, and determined its comparability with histamine challenge. The exercise challenge was 6 minutes of outdoor, free-range running at 85-90% of maximum heart rate, measured by heart rate monitor. Nose clips were worn. Distance run was measured to estimate oxygen consumption. Water content of the inspired air was < 10 mg H2O.l-1. Histamine challenge was by the rapid method. We used questionnaires to measure respiratory symptoms and skin prick tests to measure atopy. A total of 96 children aged 8-11 years were studied. Bronchial hyperresponsiveness (BHR) to exercise challenge was defined as a fall in forced expiratory volume in one second (FEV1) of 13% of greater. Eleven children had a positive response to exercise challenge and 11 to histamine challenge but 12 responded to one challenge and not to the other. The correlation coefficient between the two tests was 0.65 (p = 0.0001). Exercise challenge thus proved to be a practical epidemiological tool for objective measurements of bronchial responsiveness in children. In this sample, some children responded to one challenge and not to the other which suggests that the two challenges identify different abnormalities of the airways.
我们研究了运动激发试验方案是否适用于儿童哮喘流行病学研究中支气管反应性的测量，并确定其与组胺激发试验的可比性。运动激发试验为在户外自由奔跑6分钟，心率通过心率监测仪测量，强度为最大心率的85 - 90%。试验时佩戴鼻夹。测量跑步距离以估算耗氧量。吸入空气的含水量<10 mg H2O·l-1。组胺激发试验采用快速法。我们使用问卷来测量呼吸道症状，并用皮肤点刺试验来测量特应性。共研究了96名8 - 11岁的儿童。运动激发试验的支气管高反应性（BHR）定义为一秒用力呼气容积（FEV1）下降13%及以上。11名儿童运动激发试验呈阳性反应，11名组胺激发试验呈阳性反应，但有12名儿童对一种激发试验有反应，对另一种则无反应。两种试验的相关系数为0.65（p = 0.0001）。因此，运动激发试验被证明是一种用于客观测量儿童支气管反应性的实用流行病学工具。在这个样本中，一些儿童对一种激发试验有反应，对另一种则无反应，这表明两种激发试验识别出了气道的不同异常情况。
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