体内暴露于氟化钠不会改变病毒诱导的肿瘤性骨膜骨的产量，也不会改变人肿瘤KB细胞在小鼠体内诱导的异位骨的产量。
In vivo exposure to sodium fluoride does not modify the yield of viral tumour-induced periosteal bone nor of heterotopic bone induced by human tumour KB cells in mice.
作者信息
Włodarski P K, Włodarski K H, Galus K, Skarpetowski A C, Kowalski M, Luczak M, Marciniak M M
机构信息
Department of Histology, Institute of Biostructure, Medical School, Warsaw, Poland.
出版信息
Folia Biol (Praha). 1995;41(2):88-96.
In mice local or systemic administration of fluoride (5-25 mg NaF/kg body weight) during the proliferative phase of bone formation (up to 20 days) has no effect on the yield of bone formed either by local stimulation of periosteal membrane by Moloney sarcoma virus-induced tumour or on bone induced heterotopically by human KB cells. The lack of stimulatory activity of fluoride on rapidly induced osteogenesis in mice is in agreement with recent reports which show that fluoride is not a potent mitogen for human osteoblasts grown in vitro.
在小鼠骨骼形成的增殖期（长达20天），局部或全身给予氟化物（5 - 25毫克氟化钠/千克体重），对于莫洛尼肉瘤病毒诱导的肿瘤局部刺激骨膜形成的骨产量，或人KB细胞异位诱导形成的骨产量均无影响。氟化物对小鼠快速诱导成骨缺乏刺激活性，这与最近的报道一致，这些报道表明氟化物对体外培养的人成骨细胞不是一种有效的促有丝分裂原。
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