Włodarski K H, Reddi H A
Arch Immunol Ther Exp (Warsz). 1986;34(5-6):583-93.
Heterotopic bone induced in mice by implantation of demineralized rat bone matrix does not respond to Moloney sarcoma. The biochemical and morphological parameters of osteogenesis (alkaline and acid phosphatase activity, 45Ca-uptake and total calcium content) are similar in the sites of Moloney sarcoma as in the contralateral, unexposed to the sarcoma, side. In contrast, periosteum of implants of syngeneic costal bone in response to Moloney sarcoma proliferates and produces new bone in the same manner, as orthotopic bones at the sites of Moloney sarcoma do. It is concluded that ectopically induced bones do not develop a true periosteum.
通过植入脱矿大鼠骨基质在小鼠体内诱导生成的异位骨对莫洛尼肉瘤无反应。在莫洛尼肉瘤部位，成骨的生化和形态学参数（碱性和酸性磷酸酶活性、45Ca摄取和总钙含量）与对侧未暴露于肉瘤的部位相似。相比之下，同基因肋骨植入物的骨膜对莫洛尼肉瘤有反应，其增殖并产生新骨的方式与莫洛尼肉瘤部位的原位骨相同。得出的结论是，异位诱导的骨不会发育出真正的骨膜。
