[内源性高甘油三酯血症患者血浆极低密度脂蛋白、低密度脂蛋白及高密度脂蛋白的脂质和载脂蛋白组成研究]

[Study on lipid and apolipoprotein composition of plasma VLDL, LDL and HDL in endogenous hypertriglyceridemia].

作者信息

Fan P, Liu B

出版信息

Hua Xi Yi Ke Da Xue Xue Bao. 1995 Mar;26(1):6-10.

Abstract

We analysed the lipid and apolipoprotein (apo) composition of plasma VLDL, LDL and HDL including TG, FC, CE, PL and apoA I, A II, B100, C II, C III and E in 20 endogenous HTG patients whose plasma TG levels were > 2.26 mmol/L, TC < 6.74 mmol/L and in 20 normal subjects whose plasma lipid levels were normal (TG < 1.70 mmol/L, TC < 5.96 mmol/L). The results showed that the fasting plasma TG, apoC II, C III and E levels were significantly higher and HDL-C and apo A I levels lower in the HTG group than those in the normal group (P < 0.05). Abnormality of lipid and apolipoprotein composition of plasma VLDL, LDL and HDL in HTG was found. TG, FC, CE, PL and apoB100, C II, C III and E contents in VLDL were significantly increased in HTG (P < 0.01), while CE, apoA I, C II, C III and E in HDL were significantly decreased (P < 0.05) and TG in HDL significantly increased (P < 0.05) in HTG. TG and apoB100 in LDL in the HTG group were higher than those in the normal group (P < 0.05).

摘要

我们分析了20例血浆甘油三酯（TG）水平>2.26 mmol/L、总胆固醇（TC）<6.74 mmol/L的内源性高甘油三酯血症（HTG）患者以及20例血脂水平正常（TG<1.70 mmol/L，TC<5.96 mmol/L）的正常受试者血浆极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）的脂质和载脂蛋白（apo）组成，包括TG、游离胆固醇（FC）、胆固醇酯（CE）、磷脂（PL）以及apoA I、A II、B100、C II、C III和E。结果显示，HTG组空腹血浆TG、apoC II、C III和E水平显著高于正常组，而HDL-C和apo A I水平低于正常组（P<0.05）。发现HTG患者血浆VLDL、LDL和HDL的脂质和载脂蛋白组成异常。HTG患者VLDL中的TG、FC、CE、PL以及apoB100、C II、C III和E含量显著增加（P<0.01），而HDL中的CE、apoA I、C II、C III和E显著降低（P<0.05），HDL中的TG显著增加（P<0.05）。HTG组LDL中的TG和apoB100高于正常组（P<0.05）。