复发性气道感染患儿鼻黏膜纤毛功能的临床与超微结构相关性研究

Clinical and ultrastructural correlations in nasal mucociliary function observed in children with recurrent airways infections.

作者信息

Armengot M, Escribano A, Carda C, Basterra J

机构信息

ENT Department, Valencia University General Hospital, Spain.

出版信息

Int J Pediatr Otorhinolaryngol. 1995 May;32(2):143-51. doi: 10.1016/0165-5876(95)01133-v.

DOI:10.1016/0165-5876(95)01133-v

PMID:7657468

Abstract

A study was made of 106 children between 1 and 15 years of age (mean 6 years) with recurrent upper and lower airways infections since birth. Nasal mucociliary transport (NMT) velocity was determined in all subjects by the Tc99m-labeled seroalbumin technique. In 42 children, NMT was found to be altered. In this group of patients the technique was repeated in a period of between 1 and 2 years later. In 23 cases (55%) transport had normalized, while in 19 (45%) it remained altered. Recurrent pneumonia and constant rhinorrhea were more frequent in this group. Situs inversus was only detected in 2 of these patients. Pathology showed ciliary ultrastructure, the absence of dynein arms and microtubule alterations. The absence of cilia was observed in some patients. Normal cilia were also encountered in children with persistently altered nasal mucociliary transport.

摘要

对106名1至15岁（平均6岁）自出生以来反复出现上、下呼吸道感染的儿童进行了一项研究。通过Tc99m标记的血清白蛋白技术测定了所有受试者的鼻黏膜纤毛传输（NMT）速度。在42名儿童中，发现NMT发生了改变。在这组患者中，1至2年后重复了该技术。在23例（55%）中传输已恢复正常，而在19例（45%）中仍未恢复正常。该组中反复肺炎和持续流涕更为常见。仅在其中2例患者中检测到内脏反位。病理学显示纤毛超微结构、动力蛋白臂缺失和微管改变。在一些患者中观察到无纤毛现象。在鼻黏膜纤毛传输持续改变的儿童中也发现了正常纤毛。