Crawford H C, Matrisian L M
Department of Cell Biology, Vanderbilt University, Nashville, Tenn. 37232, USA.
Invasion Metastasis. 1994;14(1-6):234-45.
The matrix metalloproteinases (MMPs) have been associated with tissue remodeling in many normal and pathological processes, and in particular are thought to be critical for tumor invasion and metastasis. MMP overexpression has been correlated with the stage of progression in several tumor types. Because of the aberrant nature of tumor cells, it has been assumed that the tumor cells themselves are responsible for this abnormal MMP production. However, recent in situ hybridization experiments have determined that, while some members of the MMP family are expressed within neoplastic cells, many are found in normal stromal components immediately adjacent to the tumor tissue. In this review, we address the potential roles of both tumor and stromal MMPs in tumor progression. Also, using MMP expression as a point of reference, we discuss some of the potential mechanisms involved in tumor/host interactions.
基质金属蛋白酶（MMPs）在许多正常和病理过程中都与组织重塑有关，尤其被认为对肿瘤侵袭和转移至关重要。MMP的过表达与几种肿瘤类型的进展阶段相关。由于肿瘤细胞的异常性质，人们认为肿瘤细胞自身是这种异常MMP产生的原因。然而，最近的原位杂交实验已经确定，虽然MMP家族的一些成员在肿瘤细胞内表达，但许多成员却存在于紧邻肿瘤组织的正常基质成分中。在这篇综述中，我们阐述了肿瘤和基质MMPs在肿瘤进展中的潜在作用。此外，以MMP表达作为参考点，我们讨论了肿瘤/宿主相互作用中涉及的一些潜在机制。
