Walz D A, Fenton J W
Department of Physiology, Wayne State University, Detroit, Mich 48201, USA.
Invasion Metastasis. 1994;14(1-6):303-8.
The relationship between malignancy and thrombosis and hemostasis has long been recognized but is poorly understood. The interaction of tumor cells and the proteins and cells of coagulation is symbiotic and complex. Selected cancers have been known to respond to antithrombotic and anticoagulant therapies such as warfarin, heparin and most recently, hirudin. The identification of the functional 'tethered ligand' thrombin receptor on platelets, other cells and recently tumor cells has provided additional opportunities to examine and control the course of tumor proliferation. Thrombin, at concentrations which precede fibrin formation, is a potent inducer of tumor cell expression of various integrin receptors and tumor cell adhesion to the matrix and other activated cells. New strategies based on specifically controlling the action of thrombin may be beneficial in arresting the proliferation of these cells.
恶性肿瘤与血栓形成及止血之间的关系早已为人所知，但人们对此了解甚少。肿瘤细胞与凝血蛋白及细胞之间的相互作用是共生且复杂的。已知某些特定癌症对抗血栓和抗凝疗法有反应，如华法林、肝素以及最近的水蛭素。血小板、其他细胞以及最近在肿瘤细胞上发现的功能性“拴系配体”凝血酶受体，为研究和控制肿瘤增殖过程提供了更多机会。在纤维蛋白形成之前的浓度下，凝血酶是肿瘤细胞表达各种整合素受体以及肿瘤细胞与基质和其他活化细胞黏附的强力诱导剂。基于特异性控制凝血酶作用的新策略可能有助于阻止这些细胞的增殖。
