Nierodzik Mary Lynn, Karpatkin Simon
New York University School of Medicine, Department of Medicine/Hematology, 550 First Avenue, New York, New York 10016, USA.
Cancer Cell. 2006 Nov;10(5):355-62. doi: 10.1016/j.ccr.2006.10.002.
The association of idiopathic venous thrombosis with occult cancer is generally recognized. However, it has not been fully appreciated that thrombin generated during thrombosis can augment the malignant phenotype. Thrombin activates tumor cell adhesion to platelets, endothelial cells, and subendothelial matrix proteins; enhances tumor cell growth; increases tumor cell seeding and spontaneous metastasis; and stimulates tumor cell angiogenesis. These mechanisms are reviewed. Evidence is also presented to support the hypothesis that thrombin serves to preserve dormant tumor cells in individuals, preventing host eradication. It is proposed that tumor malignancy may be regulated by a procoagulant/anticoagulant axis.
特发性静脉血栓形成与隐匿性癌症之间的关联已得到普遍认可。然而，血栓形成过程中产生的凝血酶可增强恶性表型这一点尚未得到充分认识。凝血酶激活肿瘤细胞与血小板、内皮细胞及内皮下基质蛋白的黏附；促进肿瘤细胞生长；增加肿瘤细胞播种和自发转移；并刺激肿瘤细胞血管生成。本文对这些机制进行了综述。同时也提供了证据支持凝血酶可保护个体体内休眠肿瘤细胞、防止宿主清除的假说。有人提出肿瘤恶性程度可能受促凝/抗凝轴调控。
