Valdez R A, Gelberg H B, Morin D E, Zuckermann F A
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
J Am Vet Med Assoc. 1995 Sep 15;207(6):761-5.
Pemphigus foliaceus was diagnosed in a 20-month-old female pygmy goat. The goat had a 3-month history of chronic exfoliative dermatitis and was examined after developing alopecia and severe, asymmetric, diffuse flakes of dry, nonadherent skin scales. Pemphigus foliaceus was diagnosed on the basis of dermatohistologic findings and was confirmed by analysis of results of direct immunofluorescence testing of perilesional specimens obtained by use of a punch biopsy. The goat was successfully treated with prednisolone (immunosuppressive induction dosage; 1 mg/kg of body weight, IM, q 12 h). Remission was achieved in 1 week and was maintained by use of prednisolone (immunosuppressive maintenance dosage; 1 mg/kg, IM, q 48 h). Treatment with aurothioglucose (1 mg/kg, IM, q 7 d) that was initiated during administration of prednisolone and was continued after discontinuation of corticosteroid administration failed to prevent redevelopment of pemphigus foliaceus.
在一只20个月大的雌性侏儒山羊身上诊断出落叶型天疱疮。这只山羊有3个月的慢性剥脱性皮炎病史，在出现脱毛以及严重、不对称、弥漫性的干燥、不粘连皮肤鳞屑后接受了检查。根据皮肤组织学检查结果诊断为落叶型天疱疮，并通过对使用打孔活检获取的损害周围标本进行直接免疫荧光检测结果分析得以确诊。这只山羊用泼尼松龙成功治疗（免疫抑制诱导剂量；1毫克/千克体重，肌肉注射，每12小时一次）。1周内实现缓解，并通过使用泼尼松龙（免疫抑制维持剂量；1毫克/千克，肌肉注射，每48小时一次）维持。在泼尼松龙给药期间开始并用硫代葡萄糖金（1毫克/千克，肌肉注射，每7天一次）治疗，在停用皮质类固醇后继续治疗，但未能防止落叶型天疱疮再次发生。
