咖啡因对酵母中溴化乙锭诱导的小菌落突变的保护作用。

A protective effect of caffeine on the ethidium induced petite mutation in yeast.

作者信息

Hixon S C, Yielding K L

出版信息

Mutat Res. 1976 Feb;34(2):195-200. doi: 10.1016/0027-5107(76)90124-x.

DOI:10.1016/0027-5107(76)90124-x

Abstract

A prerequisite for petite induction by ethidium bromide (EB) is an initial covalent attachment of the drug to cytoplasmic DNA. This DNA modification is thought to initiate repair processes. The repair inhibitor, caffeine, provided a protective effect against the ethidium induced petite mutation at caffeine concentrations known to inhibit the repair of UV damage in cytoplasmic DNA (Fig. 1). Mitochondrial DNA isolated from yeast exposed to EB in vivo was not as degraded in the presence of both drugs as with EB alone (Fig. 2).

摘要

溴化乙锭（EB）诱导小菌落形成的一个先决条件是该药物最初与细胞质DNA发生共价连接。这种DNA修饰被认为会启动修复过程。修复抑制剂咖啡因在已知能抑制细胞质DNA中紫外线损伤修复的浓度下，对EB诱导的小菌落突变具有保护作用（图1）。从体内暴露于EB的酵母中分离出的线粒体DNA，在两种药物共同存在的情况下，不像单独使用EB时那样降解（图2）。

相似文献

1

A protective effect of caffeine on the ethidium induced petite mutation in yeast.咖啡因对酵母中溴化乙锭诱导的小菌落突变的保护作用。

Mutat Res. 1976 Feb;34(2):195-200. doi: 10.1016/0027-5107(76)90124-x.

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