咖啡因对酿酒酵母中溴化乙锭诱导rho的影响。
Effect of caffeine on the rho- -induction with ethidium bromide in Saccharomyces cerevisiae.
作者信息
Wolf K, Kaudewitz F
出版信息
Mol Gen Genet. 1976 Jul 5;146(1):89-93. doi: 10.1007/BF00267987.
PMID:785213
Abstract
It is shown that caffeine antagonizes petite-induction with ethidium bromide under non-growth conditions when administered during or after mutagenic treatment. Caffeine itself is shown to be a petite-inducing agent when cells are grown in liquid glucose-complete-medium in the presence of the drug. A possible mode of action of caffeine in the ethidium bromide induced petite-mutagenesis is discussed.
摘要
结果表明，在诱变处理期间或之后给予咖啡因，在非生长条件下它能拮抗溴化乙锭诱导的小菌落形成。当细胞在含有该药物的液体葡萄糖完全培养基中生长时，咖啡因本身被证明是一种诱导小菌落形成的因子。本文讨论了咖啡因在溴化乙锭诱导的小菌落诱变中的一种可能作用模式。
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