Westensen K, Bunjes H, Koch M H
Institute for Pharmaceutical Technology, University of Braunschweig, Germany.
J Pharm Sci. 1995 May;84(5):544-50. doi: 10.1002/jps.2600840506.
The influence of admixture of Triton X100 to the polymer tyloxapol and the phase behavior of the mixtures in contact with water was investigated by viscometry, polarization microscopy, and X-ray scattering. The viscosity of tyloxapol/Triton X100 mixtures is lower than that of pure tyloxapol. With increasing Triton X100 content, the phase behavior of the surfactant mixtures in contact with water evolves from the complex behavior of tyloxapol to the simpler one of Triton X100. In contact with water, mixtures rich in tyloxapol form hexagonal, cubic, and lamellar lyotropic liquid crystalline phases over a wide range of concentration and temperature, whereas Triton X100/water mixtures form only a hexagonal phase in a limited concentration and temperature range. The polymeric nature of tyloxapol stabilizes the liquid crystalline structures, and the size of the supramolecular structures in the water-containing surfactant systems is independent of the tyloxapol/Triton X100 mixing ratio but depends highly on water content. The ability of tyloxapol to form stable lyotropic liquid crystalline phases at body temperature, which has been proposed as a basis for the development of novel peroral sustained-release systems, is not significantly impaired by the addition of appropriate amounts of Triton X100. Admixture of Triton X100 to tyloxapol may thus provide a way to circumvent processing problems during the preparation of pharmaceutical formulations based on the highly viscous tyloxapol.
通过粘度测定法、偏光显微镜和X射线散射研究了向聚合物泰洛沙泊中添加Triton X100的影响以及该混合物与水接触时的相行为。泰洛沙泊/Triton X100混合物的粘度低于纯泰洛沙泊的粘度。随着Triton X100含量的增加，与水接触的表面活性剂混合物的相行为从泰洛沙泊的复杂行为演变为Triton X100的较简单行为。与水接触时，富含泰洛沙泊的混合物在很宽的浓度和温度范围内形成六方相、立方相和层状溶致液晶相，而Triton X100/水混合物仅在有限的浓度和温度范围内形成六方相。泰洛沙泊的聚合物性质稳定了液晶结构，含水电表面活性剂体系中超分子结构的大小与泰洛沙泊/Triton X100混合比例无关，但高度依赖于水含量。泰洛沙泊在体温下形成稳定溶致液晶相的能力（这已被提议作为新型口服缓释系统开发的基础）不会因添加适量的Triton X100而受到显著损害。因此，向泰洛沙泊中添加Triton X100可能提供一种方法，以规避在制备基于高粘性泰洛沙泊的药物制剂过程中的加工问题。
