Flickinger C J, Herr J C, Baran M L, Howards S S
Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, USA.
J Urol. 1995 Oct;154(4):1539-44.
Aims were to determine the effects of obstruction of the vas deferens prior to sexual maturation on testicular growth and the formation of spermatic granulomas.
The vas deferens was ligated and divided bilaterally in 10-day-old Lewis rats.
Testis weight and volume did not differ significantly between obstructed rats and sham controls at the majority of the intervals studied, including the end of the experiment at 128 days, although some temporary changes were observed. Testes of obstructed animals showed normal histological differentiation. Nearly all obstructed animals developed spermatic granulomas of the epididymis once they matured.
When obstructed prior to sexual maturation, the testes are affected only transiently, but significant epididymal alterations occur. Spermatic granulomas are located predominantly in the epididymis rather than the vas deferens.
旨在确定性成熟前输精管阻塞对睾丸生长及精子肉芽肿形成的影响。
在10日龄的Lewis大鼠中双侧结扎并切断输精管。
在大多数研究间隔期，包括实验结束时的128天，阻塞组大鼠与假手术对照组的睾丸重量和体积无显著差异，尽管观察到一些暂时变化。阻塞组动物的睾丸显示出正常组织学分化。几乎所有阻塞组动物成熟后均出现附睾精子肉芽肿。
性成熟前阻塞输精管时，睾丸仅受到短暂影响，但附睾会发生显著改变。精子肉芽肿主要位于附睾而非输精管。
